Table 2.
Summary of Biomarkers with Significant Global Ancestry Association for Either African or Asian Global Ancestry (p < 0.05/237)
| Biomarker | Global African Ancestry | Global Asian Ancestry | ||
|---|---|---|---|---|
| β and p Value | β (95% CI) | p Value | β (95% CI) | p Value |
| Kallikrein 5 | −0.33 (−0.40, −0.25) | <5 × 10−10 | 0.21 (0.02, 0.40) | 0.027 |
| vitronectin | −0.29 (−0.33, −0.25) | <5 × 10−10 | 0.07 (−0.45, 0.59) | 0.79 |
| factor VII | −0.24 (−0.27, −0.21) | <5 × 10−10 | 0.03 (−0.19, 0.25) | 0.81 |
| insulin-like growth factor binding protein 5 | 0.17 (0.13, 0.22) | 1.8 × 10−15 | −0.15 (−0.50, 0.20) | 0.40 |
| immunoglobulin M | 0.24 (0.18, 0.30) | 5.3 × 10−15 | 0.00 (−0.31, 0.31) | 0.98 |
| apolipoprotein B | −0.74 (−0.93, −0.55) | 6.2 × 10−14 | 0.04 (−0.33, 0.40) | 0.84 |
| monocyte chemotactic protein 4 | 0.54 (0.39, 0.69) | 1.6 × 10−12 | 0.08 (0.02, 0.14) | 0.011 |
| interleukin-12 subunit p40 | −0.08 (−0.10, −0.06) | 3.2 × 10−12 | 0.01 (−0.22, 0.24) | 0.95 |
| resistin | 0.34 (0.24, 0.44) | 1.3 × 10−11 | 0.01 (−0.20, 0.22) | 0.95 |
| hepatocyte growth factor receptor | −0.27 (−0.35, −0.18) | 1.3 × 10−9 | 0.10 (−0.34, 0.55) | 0.65 |
| ficolin-3 | −0.13 (−0.17, −0.09) | 9.0 × 10−9 | −0.19 (−0.48, 0.09) | 0.19 |
| protein S100-A4 | 0.55 (0.35, 0.75) | 7.3 × 10−8 | 0.07 (−0.04, 0.17) | 0.22 |
| cortisol | −0.41 (−0.58, −0.25) | 6.5 × 10−7 | −0.13 (−0.38, 0.13) | 0.33 |
| 6Ckine | −0.27 (−0.38, −0.16) | 1.1 × 10−6 | −0.18 (−0.39, 0.02) | 0.080 |
| immunoglobulin E | 0.37 (0.22, 0.52) | 1.4 × 10−6 | 0.45 (0.16, 0.74) | 0.0020 |
| hepatocyte growth factor | −0.46 (−0.65, −0.26) | 3.2 × 10−6 | −0.18 (−0.37, 0.02) | 0.073 |
| ferritin | −0.36 (−0.52, −0.20) | 1.5 × 10−5 | −0.03 (−0.36, 0.30) | 0.86 |
| adrenomedullin | −0.62 (−0.90, −0.33) | 2.0 × 10−5 | −0.23 (−0.54, 0.07) | 0.13 |
| creatine kinase-MB | −0.61 (−0.89, −0.32) | 3.0 × 10−5 | −0.10 (−0.48, 0.28) | 0.61 |
| prostatic acid phosphatase | −0.26 (−0.38, −0.14) | 3.4 × 10−5 | −0.07 (−0.17, 0.02) | 0.13 |
| methylglyoxal | −0.50 (−0.74, −0.25) | 6.8 × 10−5 | −0.05 (−0.54, 0.44) | 0.83 |
| glucose-6-phosphate isomerase | 0.40 (0.20, 0.60) | 8.1 × 10−5 | 0.17 (−0.37, 0.71) | 0.54 |
| sex hormone-binding globulin | 0.26 (0.13, 0.40) | 0.00015 | 0.17 (−0.11, 0.45) | 0.24 |
| mesothelin | 0.25 (−0.01, 0.52) | 0.064 | 0.22 (0.14, 0.29) | 3.2 × 10−8 |
| thrombospondin-1 | 0.00 (−0.24, 0.24) | 0.99 | 0.12 (0.08, 0.17) | 1.21 × 10−7 |
| pulmonary and activation-regulated chemokine | 0.27 (−0.08, 0.62) | 0.13 | 0.25 (0.16, 0.35) | 5.4 × 10−7 |
| T lymphocyte-secreted protein I-309 | 0.23 (0.05, 0.41) | 0.014 | −0.07 (−0.11, −0.04) | 1.9 × 10−5 |
| pigment epithelium derived factor | −0.01 (−0.15, 0.14) | 0.92 | −0.26 (−0.39, −0.14) | 4.6 × 10−5 |
| chemokine CC-4 | 0.00 (−0.09, 0.09) | 0.98 | −0.53 (−0.79, −0.27) | 5.5 × 10−5 |
β per SD increase in global ancestry. Global ancestry is included as fixed effects in the variance component model. Biomarkers were residualized for age and sex.
CI = confidence interval