Table 1.

Characteristics of the most used anesthetics in dermatology.

Anesthetic	Protein affinity	Onset of action	Duration without epinephrine (min)	Duration with epinephrine (min)
Amide type
Lidocaine	64	2–3 min	30–120	60–400
Mepivacaine	77	3–20 min	30–120	60–400
Bupivacaine	95	5–8 min	120–240	240–480
Ester type
Procaine	5.8	5 min	15–30	30–90

Adapted from Koay et al, 2012 and Park et al, 2017 5, 6