Tract exhibiting significant associations between changes in estradiol and changes in FA in females only. Data and trends plotted include adjustment of covariates (Time 1 levels of testosterone, Time 1 age, FA of tract at Time 1, time of saliva collection, motion during scan, and tract length) on FA (i.e., regressing out the effects of these covariates). Change in estradiol refers to the difference in log (ln) transformed estradiol values scaled by the interval between timepoints. See Tables 4A, 4B, 4C for more details.