Table 5.

Summary of estimates from modeling the effects of changes in testosterone on changes in MD, RD, and AD. All models include Time 1 levels of testosterone, Time 1 age, Time 1 diffusivity metric of tract, time of saliva collection, motion during scan, and tract length as covariates. We also report the simple slopes for males and females for any tracts exhibiting significant interaction effects (at uncorrected significance values), as well as partial values for any significant interaction effects and effects of testosterone in females, and the adjusted R² for the full models. *indicates significance at p < 0.05; **indicates significance at p < 0.01.

Tract	Diffusivity Metric	β±SE	Statistic	Significance (uncorrected)	Partial R2	Adjusted R2
L CST	MD	Interaction: 0.29 ± 0.03Males: 0.15 ± 0.01Females: -0.33  ± 0.02	Interaction: t(68) = 2.32Males: t(21) = 0.14 Females: t(41)=-3.01	Interaction: p = 0.023*Males: p = 0.89Females: p = 0.005**	Interaction: R2 = 0.07Females: R2 = 0.18	All: R2 = 0.62 Males: 0.75 Females: R2 = 0.60
R CST	MD	Interaction: 0.28 ± 0.03Males: 0.22 ± 0.01Females: -0.30  ± 0.02	Interaction: t(68) = 2.10Males: t(21) = 0.21 Females: t(41)=-2.60	Interaction: p = 0.039*Males: p = 0.84Females: p = 0.013*	Interaction: R2 = 0.06Females: R2 = 0.14	All: R2 = 0.59 Males: 0.76 Females: R2 = 0.56
L CST	RD	Interaction: 0.31 ± 0.03Males: 0.03 ± 0.02Females: -0.32.  ± 0.02	Interaction: t(68) = 2.45Males: t(21) = 0.25 Females: t(41)=-2.91	Interaction: p = 0.016*Males: p = 0.80Females: p = 0.006**	Interaction: R2 = 0.08Females: R2 = 0.17	All: R2 = 0.61 Males: 0.74 Females: R2 = 0.59
R CST	RD	Interaction: 0.44 ± 0.02Males: 0.03 ± 0.01Females: -0.34.  ± 0.02	Interaction: t(68) = 2.21Males: t(21) = 0.26 Females: t(41)=-2.67	Interaction: p = 0.031*Males: p = 0.79Females: p = 0.01*	Interaction: R2 = 0.07Females: R2 = 0.15	All: R2 = 0.52 Males: 0.65 Females: R2 = 0.49
CC Minor	AD	Interaction: -0.38 ± 0.05Males: -0.19 ± 0.02Females: 0.38  ± 0.03	Interaction: t(70)=-2.10 Males: t(21)=-1.04 Females: t(43) = 2.99	Interaction: p = 0.018*Males: p = 0.31Females: p = 0.005**	Interaction: R2 = 0.07Females: R2 = 0.15	All: R2 = 0.39Males: R2 = 0.39Females: R2 = 0.40
L CGC	AD	Interaction: -0.41 ± 0.04Males: -0.33 ± 0.02Females: 0.47  ± 0.03	Interaction: t(67)=-2.68 Males: t(21)=-0.02 Females: t(40) = 3.85	Interaction: p = 0.009**Males: p = 0.98Females: p = 0.004**	Interaction: R2 = 0.10Females: R2 = 0.27	All: R2 = 0.46Males: R2 = 0.53Females: R2 = 0.48
R CGC	AD	Interaction: -0.34 ± 0.04Males: -0.62 ± 0.03Females: 0.35  ± 0.03	Interaction: t(66)=-2.15 Males: t(20)=-0.32 Females: t(40) = 2.80	Interaction: p = 0.035* Males: p = 0.75Females: p = 0.008**	Interaction: R2 = 0.10Females: R2 = 0.16	All: R2 = 0.42Males: R2 = 0.36Females: R2 = 0.46