Figure 2.

p62 and its function in selective autophagy and aggregate clearance. (a) Schematic overview of p62-dependent selective autophagy and aggregate clearance. P62 directs intracellular cargo to the phagophore. A double membrane vesicle is formed that fuses with the lysosome to degrade its content. (b) Schematic overview of the p62 domain organization. Cargo-binding sites are indicated below; vtRNA1-1 mediated regulation of p62 effector function is depicted above.