Table 1.

List of TCR-like CAR-T cells.

Antigen	MHC	Epitope	Target disease	Method	Library size	Immunization	Screening	Clone	Affinity (KD)	CAR signaling domains	References
MAGE-A1	HLA-A1	EADPTGHSY	Cancer	Phage	3.7 × 1010	–	pMHC	G8	250 nM	CD4–FcεRIγ	(18)
MAGE-A1	HLA-A1	EADPTGHSY	Cancer	Phage	3.7 × 1010	–	pMHC	G8 Hyb3	250 nM 14 nM	CD28–FcεRIγ	(23)
NY-ESO-1	HLA-A*02:01	SLLMWITQC	Cancer	Phage	1.45 × 1010	–	pMHC	T1	2–4 nM	CD28–CD3ζ	(24)
WT1	HLA-A*02:01	RMFPNAPYL	Cancer	Phage	3.7 × 1010	–	pMHC	F2 F3	400 nM 30 nM	CD28- FcγRIγ	(25)
HMHA1	HLA-A*02:01	VLHDDLLEA	Blood cancer	Phage	5 × 108	+	pMHC	#131	19.9 nM	CD28–CD3ζ	(22)
GP100	HLA-A*02:01	ITDQVPFSV	Melanoma	Phage	5.4 × 108	–	pMHC	GPA7	183 nM	CD3ζ	(26)
WT1	HLA-A*02:01	RMFPNAPYL	Cancer	Phage	2.85 × 108	–	pMHC	Q2L	3 nM	CD137–CD3ζ	(27)
AFP	HLA-A*02:01	FMNKFIYEI	Hepatoma	Phage	9 × 1010	–	pMHC	ET1402L1	0.03–0.2 nM	CD28–CD3ζ	(29)
WT1	HLA-A*02:01	RMFPNAPYL	Cancer	Phage	7 × 1010	–	pMHC	ESK1	0.1 nM	CD28–CD3ζ	(30)
WT1	HLA-A*24:02	CYTWNQMNL	Cancer	Phage	NA	–	pMHC	#213	741 nM	CD3ζ-CD357	(31)
Insulin	H-2 I-Ag7	B:9–23 peptide	Autoimmune diabetes	Hybridoma	850	+	pMHC	mAb287	120 nM	CD28–CD3ζ, CD28–CD137–CD3ζ	(32)