Table 7.
Inhibitory effects of positive control and 1–13 on NO production in RAW 264.7 cells.
No. | NRC (%) | No. | NRC (%) | No. | NRC (%) |
---|---|---|---|---|---|
Normal | 1.5 ± 0.5 | 4 | 102.2 ± 3.1 | 10 | 91.5 ± 2.6** |
Control | 100.0 ± 3.3 | 5 | 73.3 ± 2.6*** | 11 | 56.5 ± 3.5*** |
DEX | 71.8 ± 0.9*** | 6 | 103.8 ± 3.0 | 12 | 97.4 ± 1.1 |
1 | 101.6 ± 3.7 | 7 | 90.4 ± 2.6** | 13 | 10.5 ± 0.3*** |
2 | 99.2 ± 1.9 | 8 | 90.2 ± 0.7** | ||
3 | 99.9 ± 2.3 | 9 | 92.2 ± 2.4** |
N, Unstimulated normal (negative control); C, Control group (stimulated by LPS); D, Dexamethasone (Dex, a positive control). Nitrite relative concentration (NRC): percentage of control group, which set as 100%. Values represent the mean ± SD of three determinations.
P < 0.01;
P < 0.001 (differences between the compound-treated group and the control group). n = 4. Final concentration was 20 μM for 1–13, and 1 μg/ml for Dex, respectively.