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Schematic representation of the genomic mechanism of corticosteroids in tissues and the influence of estrogens on glucocorticoid signaling. ER, estrogen receptor; FKBP, FK506 binding protein; GR, glucocorticoid receptor; hsp 70/90, heat shock protein 70/90; nGRE, negative glucocorticoid response element; RNAP, RNA polymerase. Figure adapted from (Ayyar et al., 2017b).
