Skip to main content
. 2020 Apr;72(2):414–438. doi: 10.1124/pr.119.018101

Fig. 6.

Fig. 6.

Pharmacodynamic scheme for receptor/gene-mediated corticosteroid action (A); measured data (circles) and model-fitted GILZ mRNA dynamics (lines) in skeletal muscle (green), lung (blue), and adipose tissue (red) after 50 mg/kg i.m. doses of methylprednisolone were given to male rats (B); and measured data (circles) and model-predicted (simulated) dynamics of GILZ mRNA (lines) in lung (blue) and adipose tissue (red) upon 0.3 mg/kg/h s.c. infusion of methylprednisolone administered to male rats over 1 week (C). The inset in (B) jointly depicts the mean PD profiles of GILZ in adipose tissue from dosed (red, solid line) and circadian control (cyan, dashed line) animals. Figure adapted from (Ayyar et al., 2017b).