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. 2019 Dec 20;37(2):248–261. doi: 10.1089/neu.2018.6333

FIG. 7.

FIG. 7.

Blast-induced tau hyperphosphorylation. Blots of brain homogenates probed for phosphorylated and total tau in rostral, middle, and caudal portions of brains. Blast animals presented a significant increase in pTau within the rostral third of the brain. (A) Tau expression normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH): rostral: 1 ± 0.07 sham, 1.09 ± 0.11 traumatic brain injury (TBI); middle: 1 ± 0.13 sham, 1.67 ± 0.32 TBI; caudal: 1 ± 0.13 sham, 1.99 ± 0.46 TBI. (B) Quantification of phospho-tau at serine 202 normalized to total tau: rostral: 1 ± 0.22 sham, 1.90 ± 0.52 TBI; middle: 1 ± 0.11 sham, 2.58 ± 0.75 TBI; caudal: 1 ± 0.14 sham, 1.07 ± 0.2 TBI. (C) Quantification of phospho-tau at serine 396 and 404 normalized to total tau: rostral: 1 ± 0.09 sham, 1.57 ± 0.21 TBI; middle: 1 ± 0.11 sham, 1.25 ± 0.12 TBI; caudal: 1 ± 0.10 sham, 1.35 ± 0.21 TBI. All samples are n = 11–12 sham and 11–12 TBI. The p values are indicated in bar graphs.