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. 2019 Nov 6;25(21-22):1493–1503. doi: 10.1089/ten.tea.2018.0371

FIG. 4.

FIG. 4.

Structural recovery of CKD by AFSC treatment. (A) Glomerular and tubular structures were restored in the AFSC group in the cortex and medulla areas, whereas vehicle tissues show fibrotic cortex (yellow arrowheads). In vehicle group, medullae show loss of brush border in tubules (blue arrowheads) and tubular dilation (black asterisk). Hematoxylin and eosin staining. Scale bar: 20 μm. (B) Masson's trichrome staining: Fibrotic areas (blue color) in the tubulointerstitial and perivascular areas of the renal cortex and medulla appear more prominent (black arrowhead), in vehicle-only group compared with AFSC and sham groups. Scale bar: 50 μm. (C) Quantitative analyses of fibrosis in the cortex and medullary regions of kidney. Collagen deposition (black arrowheads) on vehicle cortex and medulla of kidney. Each data point is a mean ± SD of 12 values.*Statistical significance (p < 0.01) compared with PBS-treated animals. Color images are available online.