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. 2019 Autumn;18(4):1843–1853. doi: 10.22037/ijpr.2019.111977.13462

Figure 2.

Activity of caspae-3 in normal and CLL B-lymphocytes. CLL and healthy B-lymphocytes (106 Cells/mL) were incubated in RPMI 1640 medium in conventional condition (37 °C and 5% CO2-air) following the addition of J. Regia and Mangifera Indica aqueous extracts to both groups. As shown in Figure 2, Mangifera Indica aqueous extract significantly increased the activity of caspae-3 in CLL B-lymphocytes BUT NOT healthy B-lymphocytes. However only Cs.A (5 µM) and BHT (5 µM) but not Z-IETD (10 µM) prevented extract induced caspase 3 activation

Figure 2

Values are expressed as mean ± SD of three separate experiments (n = 5).

***: Significant difference in comparison with CLL control (p < 0.001).

###: Significant difference in comparison with Mangifera Indica group (p < 0.001). ns indicates non-significant with control.