Table 3.
Viablity (%) of various treatment groups containing gemcitabine (IC10 concentration) exposed to 5 Gy (D50 of control group) 60Co gamma radiation. Dose enhancement ratios were calculated at 1 and 5 Gy doses
| Formulation |
Viability
|
P
-Value
†
|
DER
|
|||
|---|---|---|---|---|---|---|
| 5Gy ( 60 Co) IC Gem * | 1Gy | 5Gy | 1Gy | 5Gy | ||
| Control | 50.0 100.0 | - | - | |||
| Gem | 48.4 90.1 | 0.011 | 0.189 | 1.46 | 1.03 | |
| PLGA-Gem | 35.1 89.2 | 0.001 | 0.014 | 1.63 | 1.42 | |
| PLGA-SPION | 28.2 97.1 | 0.000 | 0.001 | 2.34 | 1.77 | |
| PLGA-SPION-Gem | 20.1 88.3 | 0.000 | 0.000 | 3.18 | 2.49 | |
*Without radiation, †Compared with the control group.