Table 3.
Physicochemical characteristics of imatinib loaded LNCs
| Formulations | Particle size (nm) | PdI | Zeta potential (mV) | Encapsulation efficiency (%) | Release efficiency (RE 48 %) |
|---|---|---|---|---|---|
| S15O10W2.5 | 38.96 ± 0.84 | 0.24 ± 0.02 | -21.5 ± 0.61 | 99.17 ± 0.086 | 60.03 ± 4.29 |
| S15O20W2.5 | 68.66 ± 0.92 | 0.16 ± 0.05 | -21.06 ± 0.89 | 98.65 ± 0.23 | 55.19 ± 6.18 |
| S30O20W2.5 | 48.07 ± 0.26 | 0.29 ± 0.006 | -13.63 ± 0.30 | 98.02 ± 0.43 | 61.6 ± 6.63 |
| S30O10W2.5 | 25.44 ± 1.84 | 0.17 ± 0.02 | -19.85 ± 1.54 | 99.34 ± 0.28 | 59.69 ± 3.36 |
| S30O20W1.2 | 39.12 ± 0.64 | 0.19 ± 0.032 | -15.6 ± 1.05 | 98.07 ± 0.28 | 56.09 ± 5.86 |
| S15O20W1.2 | 30.2 ± 2.04 | 0.34 ± 0.037 | -27.95 ± 2.1 | 98.07 ± 0.19 | 53.98 ± 7.36 |
| S30O10W1.2 | 37.64 ± 5.32 | 0.23 ± 0.06 | -15.77 ± 1.004 | 97.07 ± 0.105 | 62.49 ± 2.46 |
| S15O10W1.2 | 110.92 ± 10.39 | 0.23 ± 0.02 | -28.6 ± 2.007 | 99.35 ± 0.014 | 48.25 ± 6.5 |
S: Surfactant%; O: Oil phase%; W: Volume ratio of the diluting aqueous phase to the initial emulsion.