Table 1.
Cytotoxic effect of S-allyl cysteine ester-caffeic acid amide hybrids on SW480 and CHO K1 cell lines
| Compounds |
24 h
|
48 h
|
||||
|---|---|---|---|---|---|---|
|
IC
50
(mM)
CHO-K1 cells |
IC
50
(mM)
SW480 cells |
SI |
IC
50
(mM)
CHO-K1 cells |
IC
50
(mM)
SW480 cells |
SI | |
| 3a | 1.85 | >10 | <0.19 | >10 | >10 | >1.0 |
| 3c | 1.50 | >10 | <0.15 | 1.24 | 1.28 | 0.97 |
| 6a | 2.77 | 0.67 | 4.2 | 7.83 | >10 | <0.78 |
| 6b | 3.84 | >10 | <0.38 | >10 | >10 | >1.0 |
| 6c | 0.27 | 1.02 | 0.26 | 1.25 | >10 | <0.13 |
| 6d | 0.21 | 2.79 | 0.08 | 9.97 | >10 | <1.0 |
| 6e | 0.26 | 0.68 | 0.40 | 1.84**** | 0.18* | 10.3 |
| 9a | 0.47 | 0.24 | 2.0 | 0.18** | 0.12* | 1.5 |
| 9b | >10 | 0.93 | >10.75 | >10**** | 0.12* | >83.33 |
| 9c | 0.12 | 0.10 | 1.2 | >10**** | 0.11* | >90.91 |
| 9d | >10 | 0.11 | >90.91 | >10**** | 0.15* | >66.67 |
| 9e | 0.21 | 0.20 | 1.03 | >10**** | 0.12* | >83.33 |
| S-Allylcysteine | >10 | >10 | >1.0 | >10 | 0.38 | >26.32 |
| Caffeic acid | >10 | 7.06 | >1.42 | >10 | 3.47 | >2.88 |
| 5-Fluorouracil | 0.091 | 0.062 | 1,48 | 0.048 | 0.035 | 1.34 |
The IC50 values were obtained from dose response curves for each compound. Selectivity index was determined as ratio of IC50 against CHO-K1 to that of IC50 against SW480.