Figure 6.

The Sema3A-induced collapse was suppressed by ubiquitin-proteasome pathway inhibitors. (A) Immunofluorescence images of phalloidin staining in growth cones. The Sema3A-induced collapse was suppressed in the presence of ubiquitin-proteasome pathway inhibitors (MG132 and PYR-41), Scale bar: 10 μm. (B) Quantification of collapse rates of growth cones as in (A). In the presence of ubiquitin-proteasome pathway inhibitors, Sema3A-induced collapse was partially suppressed. Data represent mean ± SEM for n = 15. **p < 0.01, ***p < 0.001, significantly different using two-way ANOVA with Tukey’s multiple comparison test. n.s., not significant.