Skip to main content
. 2020 Mar 3;30(9):3149–3163.e6. doi: 10.1016/j.celrep.2020.02.008

Figure 6.

Figure 6

Differential Rupture Rate and Stromal Cell Response across Inbred Murine Strains

(A) Pie charts showing 1-month survival rate post-MI of 9 inbred strains with different susceptibilities to cardiovascular dysfunction, including diabetes (NOD/ShiLtJ, n = 13), obesity (NZO/HILtJ, n = 16), hypertension (129S1/SvlmJ, n = 34), calcification (DBA/2J; n = 9), dystrophic myopathy (A/J; n = 14), and wild-derived strains (CAST/EiJ, n = 18; WSB/EiJ, n = 12 and PWK/PhJ, n = 11). C57BL/6J was used as a control (n = 13).

(B) Representative whole-mount images of 129S1/SvlmJ and C57BL/6J hearts at homeostasis and d3 post-MI.

(C) t-SNE plot of combined interstitial cells from C57BL/6J and 129S1/SvlmJ hearts (B6J sham, n = 2, 4,710 cells; 129 sham, 4,213 cells; d3 MI B6J, 3,950 cells; d3 MI 129, 4,128 cells). Twenty-seven clusters were obtained using unbiased clustering.

(D) Relative ratio of various stromal cell populations in 129 and B6J hearts at d3 sham or MI (mean cells per thousand). Two B6J sham samples were used to show consistency between biological replicates.

See also Figures S5 and S6 and Table S5.