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. 2020 Feb 28;11:68. doi: 10.3389/fphar.2020.00068

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Copyright © 2020 Wang, Yu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA scores’ plot of cell metabolism trajectory in the dioscin-treated group at different time points in negative mode (A). 3D OPLS-DA score plot of cell UPLC-MS spectra data between control and 72 h dioscin-treated group in negative mode (B). Loading-plot of OPLS-DA model of UPLC-MS spectra data between control and 72 h dioscin-treated group in negative mode (C). S-plot of OPLS-DA model of UPLC-MS spectra data between control and 72 h dioscin-treated group in negative mode (D). VIP-plot of OPLS-DA model of UPLC-MS spectra data between control and 72 h dioscin-treated group in negative mode (E).