Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 28;8:87. doi: 10.3389/fcell.2020.00087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Tsogtbaatar, Landin, Minter-Dykhouse and Folmes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Transitions between human pluripotent stem cell (PSC) states. Human embryonic stem cells derived from the inner cell mass of the blastocyst or through nuclear reprogramming traditionally display a primed state associated with bivalent metabolism using both glycolysis and oxidative phosphorylation (OxPhos). Methods have now been developed to derive naïve PSCs (t2iLGö ± Y, RSeT) or to transition cells from the primed to naïve state (5i/L/AF, or Klf4, Nanog, 2i/L), resulting in a transition from bivalent metabolism to nearly exclusively glycolysis. These metabolic preferences reflect those of the related stage during embryonic development.