Halliday 1984.

Methods	Randomized Single Center Blinding of Randomization: yes (sealed envelope) Complete follow‐up: no Blinding of outcome measurement: yes Blinding of Intervention: attempted (separate staff involved in treatment administration) Long‐term follow‐up: Halliday (1986) 99% of survivors evaluated
Participants	Premature infants Gestational age 25 to 33 weeks No evidence of lung maturity No major congenital anomalies Infants randomized: DPPC/HDL = 49 Control = 51
Interventions	Intratracheal administration of dipalmitdylphosphatidylcholine 30mg/ High‐density lipoprotein 3 mg in 5 ml saline vs. manual ventilation
Outcomes	Respiratory Distress Syndrome Complications of prematurity FOLLOW‐UP: Assessed at 2 years
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	Blinding of Randomization: yes (sealed envelope)
Blinding? All outcomes	Low risk	Blinding of Intervention: attempted (separate staff involved in treatment administration) Blinding of outcome measurement: yes
Incomplete outcome data addressed? All outcomes	Unclear risk	Complete follow‐up: no Long‐term follow‐up: Halliday (1986) 99% of survivors evaluated
Free of selective reporting?	Low risk
Free of other bias?	Low risk