Figure 6.
Contribution of δ subunit-containing GABAA receptors to tonic conductance in CRF1+ and CRF1− lateral amygdala neurons. A, Representative voltage-clamp recording of a CRF1+ (left) and CRF1− (right) cell during superfusion of the δ subunit-preferring GABAA agonist THIP (5 μm). White dashed line indicates level of holding current before and after THIP superfusion. B, Summary of the tonic current induced by THIP in CRF1+ and CRF1− cells; *p < 0.05 by unpaired t test comparing CRF1+ to CRF1− cells. C, Summary of the change in rms noise induced by THIP superfusion in CRF1+ (left) and CRF1− (right) cells. *p < 0.05 by paired t test comparing differences between control and THIP 5 μm