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. 2020 Feb 28;8:138. doi: 10.3389/fchem.2020.00138

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Copyright © 2020 Rebello, Nicolardi, Lageveen-Kammeijer, Nouta, Gardner, Mesker, Tollenaar, Spencer, Wuhrer and Falck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alteration in features related to antennary fucosylated glycans for colorectal cancer patient samples. Derived traits for glycans were calculated to evaluate antennary fucosylation changes between the 14 pairs of pre-operative (Pre) vs. post-operative (Post) colorectal cancer patient samples. The patient samples were measured with the antennary fucose assay (MALDI-FT-ICR-MS readout). Significant changes were observed for antennary fucosylation in complex N-glycans (CFan), antennary fucosylation in triantennary glycans (A3Fan), antennary fucosylation in tetraantennary glycans (A4Fan), α2,3-sialylation per antenna of total antennary fucosylated glycans (CFanAm), α2,3-sialylation per antenna of diantennary antennary fucosylated glycans (A2FanAm), sialyl-Lewis x abundance (relative area%) in TPNG (SLex), Lewis x abundance in TPNG (Lex) and the ratio of sialyl-Lewis x to Lewis x abundances in TPNG (SLex / Lex). No significant changes were observed for antennary fucosylation in diantennary glycans (A2Fan), α2,3-sialylation per antenna of triantennary antennary fucosylated glycans (A3FanAm) and α2,3-sialylation per antenna of tetraantennary antennary fucosylated glycans (A4FanAm). The p-values shown are from a Wilcoxon matched-pairs signed-rank test with confidence level taken as 95%. Multiple-testing correction was performed using a false discovery rate of 1% calculated with the Benjamini and Hochberg method. The p-values < 0.0073 are considered significant and are represented with an asterisk (*).