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. 2020 Feb 28;10:263. doi: 10.3389/fonc.2020.00263

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Copyright © 2020 Sollie, Santaolalla, Michaud, Sarker, Karagiannis, Josephs, Hammar, Walldius, Garmo, Holmberg, Jungner and Van Hemelrijck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjusted dose-response association between serum levels of IgG (g/L) and risk of pancreatic cancer (HR) using restrictive cubic splines. The direction of the hazard ratios observed in Tables 2, 3 was consistent with the shape of the curve, which presents a positive association for IgG levels lower than 11.00 g/L with pancreatic cancer risk (HR > 1.00) and a protective effect for high levels of IgG (11.00–20.00 g/L) (HR <1.00). However, the inverse association was only statistically significant for concentrations of IgG between 11.00 and 16.00 g/L.