Skip to main content
. 2020 Jan 21;11(8):2260–2268. doi: 10.1039/c9sc05487a

Fig. 9. (S)-VSP-77 has potent anti-diabetic activity and does not promote fluid retention in ob/ob mice. Mice were intraperitoneally injected with vehicle, (R)-VSP-77 (5 mg kg–1), (S)-VSP-77 (5 mg kg–1), Rosi (10 mg kg–1), or orally treated with INT131 (30 mg kg–1) for 7 weeks. (A) Body weight gain. (B) Packed cell volume (PCV) in whole blood. (C) Fasting blood glucose. (D) Fasting blood insulin. (E) Blood glucose levels after an intraperitoneal glucose load (2 g kg–1) performed after 6 week treatment. The areas under the curve are indicators of glucose clearance. (F) Relative mRNA expression. (G). The level of Ser-273 phosphorylation of PPARγ in white adipose tissue by using PPARγ isoform 2. *P < 0.05 compared with vehicle (n = 6–7, error bars = SEM).

Fig. 9