TABLE 1-A1.

CDC classification system for HIV-infected adults and adolescents.

Clinical category	Conditions
A	Asymptomatic: Acute HIV or persistent generalized lymphadenopathy (PGL)
B	Conditions that are attributed to HIV infection or indicate a defect in cell-mediated immunity Conditions that are considered to have a clinical course or management that is complicated by HIV infection. Examples include, but are not limited to, the following: ■ Bacillary angiomatosis ■ Oropharyngeal candidiasis (thrush) ■ Vulvovaginal candidiasis, persistent or resistant ■ Pelvic inflammatory disease (PID) ■ Cervical dysplasia (moderate or severe)/cervical carcinoma in situ ■ Hairy leukoplakia, oral ■ Herpes zoster (shingles), involving two or more episodes or at least one dermatome ■ Idiopathic thrombocytopenic purpura ■ Constitutional symptoms, such as fever (>38.5°C) or diarrhea lasting >1 month ■ Peripheral neuropathy
C	Bacterial pneumonia, recurrent (two or more episodes in 12 months) Candidiasis of the bronchi, trachea, or lungs Candidiasis, esophageal Cervical carcinoma, invasive, confirmed by biopsy Coccidioidomycosis, disseminated or extrapulmonary Cryptococcosis, extrapulmonary Cryptosporidiosis, chronic intestinal (>1 month in duration) Cytomegalovirus disease (other than liver, spleen, or nodes) Encephalopathy, HIV-related Herpes simplex: chronic ulcers (>1 month in duration), or bronchitis, pneumonitis, or esophagitis Histoplasmosis, disseminated or extrapulmonary Isosporiasis, chronic intestinal (>1-month in duration) Kaposi sarcoma Lymphoma, Burkitt, immunoblastic, or primary central nervous system Mycobacterium avium complex (MAC) or Mycobacterium kansasii, disseminated or extrapulmonary Mycobacterium tuberculosis, pulmonary or extrapulmonary Mycobacterium, other species or unidentified species, disseminated or extrapulmonary Pneumocystis jiroveci (formerly carinii) pneumonia (PCP) Progressive multifocal leukoencephalopathy (PML) Salmonella septicemia, recurrent (nontyphoid) Toxoplasmosis of brain Wasting syndrome caused by HIV (involuntary weight loss > 10% of baseline body weight) associated with either chronic diarrhoea (two or more loose stools per day for ≥ 1 month) or chronic weakness and documented fever for ≥ 1 month

Source: Adapted from Centres for Disease Control and Prevention (CDC). (1992). Revised classification system for HIV infection and expanded surveillance case definition for AIDS Among Adolescents and Adults. Retrieved from https://www.who.int/hiv/strategic/en/cdc_1993_hivaids_def.pdf