Table 3.
PK/PD analysis of data acquired from ex vivo time-kill experiments of gamithromycin against a representative strain of H. parasuis LM15 in serums collected from each piglet (n = 6)
| Parameter (units) a | Mean ± SD (min to max) |
|---|---|
| E0 (log cfu/mL) | 0.91 ± 0.13 (0.73 to 1.05) |
| Emax (log cfu/mL) | −4.68 ± 0.06 (− 4.78 to − 4.61) |
| Emax - E0 (log cfu/mL) | − 5.59 ± 0.15 (− 5.74 to − 5.39) |
| EC50 (h) | 24.3 ± 3.88 (19.5 to 29.9) |
| Slope (N) | 4.37 ± 2.12 (2.69 to 8.34) |
| AUC24h/MIC for bacteriostatic effect (h) | 15.8 ± 4.43 (12.6 to 24.5) |
| AUC24h/MIC for bactericidal effect (h) | 30.3 ± 4.40 (24.3 to 36.4) |
| AUC24h/MIC for eradication effect (h) | 41.2 ± 7.48 (32.8 to 52.5) |
aE0, the change in log10cfu/mL after 24 h of incubation in the no drug control sample; Emax, difference in greatest amount of bacterial reduction (log10 cfu/mL); EC50 is the AUC24h/MIC producing 50% of the maximal effect; N, the slope of dose-response curve. The bacteriostatic, bactericidal and eradication effects were defined as no change, 3.0 log10 cfu/mL and 4.0 log10 cfu/mL reductions in bacterial densities