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. 2020 Feb 28;11:100. doi: 10.3389/fpsyt.2020.00100

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Copyright © 2020 Gampawar, Schmidt and Schmidt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mediation analysis of LTL on attention/speed via BPF in subgroups of BMI≥ 25 and Education ≤ 10y where LTL was significantly associated with both BPF and attention/speed. Mediation is calculated after adjusting for covariates from Model III of linear regression. a- effect of LTL on BPF, b-effect of BPF on attention/speed, c-total effect of LTL on attention/speed, and c’-direct effect of LTL on attention/speed when controlled for BPF. It shows partial mediation because total effect (c) of LTL on attention/speed is reduced in the presence of BPF (c’). LTL, Leukocyte Telomere Length; BPF, Brain Parenchymal Fraction.