Table 3.
Stratified analyses of the significant association of leukocyte telomere length (LTL) with magnetic resonance imaging (MRI) correlates and cognitive functions.
| β | SE | p | Partial R2 | β | SE | p | Partial R2 | |
|---|---|---|---|---|---|---|---|---|
| BPF | Men (313) | Women (426) | ||||||
| 0.330 | 0.174 | 0.058 | 0.008 | 0.505 | 0.155 | 0.001 | 0.016 | |
| ≤65 years (352) | >65 years (387) | |||||||
| 0.350 | 0.142 | 0.014 | 0.013 | 0.583 | 0.186 | 0.002 | 0.016 | |
| Normotensive (231) | Hypertensive (508) | |||||||
| 0.348 | 0.187 | 0.064 | 0.011 | 0.505 | 0.148 | 0.001 | 0.015 | |
| BMI <25 (266) | BMI ≥25 (473) | |||||||
| 0.502 | 0.202 | 0.013 | 0.014 | 0.403 | 0.140 | 0.004 | 0.012 | |
| Education ≤10 (505) | Education >10 (234) | |||||||
| 0.424 | 0.138 | 0.002 | 0.012 | 0.418 | 0.213 | 0.051 | 0.011 | |
| No DM (662) | DM (77) | |||||||
| 0.418 | 0.117 | 0.000 | 0.013 | 0.250 | 0.575 | 0.665 | 0.002 | |
| No CVD (437) | CVD (302) | |||||||
| 0.328 | 0.140 | 0.020 | 0.008 | 0.584 | 0.207 | 0.005 | 0.017 | |
| Apoe4 non-carriers (589) | Apoe4 carriers (140) | |||||||
| 0.485 | 0.125 | 0.000 | 0.016 | 0.149 | 0.299 | 0.620 | 0.001 | |
| WMH load |
Normotensive (258) | Hypertensive (596) | ||||||
| -0.003 | 0.015 | 0.860 | 0.000 | 0.038 | 0.016 | 0.017 | 0.008 | |
| Education ≤10 (564) | Education >10 (263) | |||||||
| 0.029 | 0.014 | 0.039 | 0.006 | 0.018 | 0.022 | 0.406 | 0.002 | |
| No DM (737) | DM (90) | |||||||
| 0.031 | 0.012 | 0.008 | 0.007 | -0.076 | 0.048 | 0.115 | 0.021 | |
| Apoe4 non-carriers (589) | Apoe4 carriers (140) | |||||||
| 0.029 | 0.013 | 0.020 | 0.006 | -0.001 | 0.030 | 0.975 | 0.000 | |
| WMH Score |
Education ≤10 (578) | Education >10 (274) | ||||||
| 0.069 | 0.030 | 0.021 | 0.008 | 0.023 | 0.047 | 0.633 | 0.001 | |
| No DM (760) | DM (92) | |||||||
| 0.061 | 0.026 | 0.018 | 0.006 | -0.049 | 0.102 | 0.633 | 0.002 | |
| No CVD (508) | CVD (344) | |||||||
| 0.060 | 0.031 | 0.049 | 0.006 | 0.042 | 0.044 | 0.343 | 0.002 | |
| Apoe4 non-carriers (674) | Apoe4 carriers (167) | |||||||
| 0.070 | 0.027 | 0.010 | 0.008 | -0.019 | 0.062 | 0.760 | 0.000 | |
| Attention /Speed |
BMI <25 (308) | BMI ≥25 (546) | ||||||
| 0.001 | 0.034 | 0.974 | 0.000 | 0.039 | 0.019 | 0.048 | 0.006 | |
| Education ≤10 (581) | Education >10 (273) | |||||||
| 0.044 | 0.022 | 0.048 | 0.005 | -0.031 | 0.025 | 0.208 | 0.005 | |
The results are shown from linear regression after adjusting for age, sex, risk factors, and ApoE4 genotypes (Model III) in subgroups. Bold shows significance level of <0.05. For each subgroup, number of participants is given in the brackets.
BPF, Brain Parenchymal Fraction ;WMH, White Matter Hyperintensities; BMI, Body Mass Index; DM, Diabetes Mellitus; CVD, Cardiovascular Disease, β-Effect size, SE-Standard Error.