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. 2020 Mar 6;14:6. doi: 10.1186/s13036-020-0231-y

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Proliferative potential of BMSCs in hydrogel-DBM composites. a Morphological observation of BMSCs in composites. Dotted lines demarcate the DBM/hydrogel interface and arrows point to spreading cells. Scale bar is 200 μm. b The proliferative potential of BMSCs measured by alamarBlue. (*) compared to MeGC or Hep-MeGC and (#) compared to MeGC-DBM 1% or Hep-MeGC-DBM 1%. *p < 0.05, ***p < 0.001, and ###p < 0.001. c H&E staining images of BMSCs cultured in composites for 2 weeks to observe the internal structure of cells and composites. Dotted lines demarcate the DBM/hydrogel interface (H: Hydrogel, D: DBM). Scale bar is 50 μm