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. 2020 Mar 6;19:15. doi: 10.1186/s12938-020-0759-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Inhibition of miR-153 ameliorated cardiac function in myocardial ischemia–reperfusion rat. Adult Sprague–Dawley rats were received the intramyocardial injection of saline (sham and I/R group), adenovirus-expressing miR-nonsense control (miR-NC), or anti-miR-153. Then, these rats were subjected to I/R treatment. LVEDD (a), LVESD (b), LVEF (c), LVFS (d), LVSP (e), and LVEDP (f) levels in the four groups were measured. g, h The influences of miR-153 on LV ± dp/dtmax were measured. n = 8 for each group. Experiments have repeated for three times independently. Data are presented as mean ± SD. *p < 0.05, **p < 0.01 compared to sham group. ^#p < 0.05 and ^##p < 0.01 compared to IR group. LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic diameter, LVEF left ventricular ejection fraction, LVFS left ventricular fraction shortening, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure