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. 2020 Mar 5;13:13. doi: 10.1186/s13072-020-00332-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DNE elicits multigenerational DNMT3A deficits in the frontal cortices and striata. Representative Western blot images and densitometric measurements of DNMT3A abundance in frontal cortices (n_F1Veh = 8, n_F1NIC = 11, and n_F2NIC = 10), striata (n_F1Veh = 9, n_F1NIC = 10, and n_F2NIC = 9), and hippocampi (n_F1Veh = 7, n_F1NIC = 7, and n_F2NIC = 7). a DNMT3A abundance in frontal cortices. F1 NIC and F2 NIC mice have reduced frontal cortical DNMT3A content. b DNMT3A abundance in striata. F1 NIC and F2 mice NIC have reduced striatal DNMT3A content. c DNMT3A abundance in hippocampi. Hippocampal DNMT3A content is unaltered in F1 NIC and F2 NIC mice. FCX frontal cortices, STR striata, HIPP hippocampi, DNMT3A DNA methyltransferase 3A, TBP TATA-binding protein. All data are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001