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. 2020 Mar 5;13:13. doi: 10.1186/s13072-020-00332-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — DNE elicits multigenerational HDAC2 deficits in the frontal cortices and hippocampi and alters HDAC2 (Ser³⁹⁴) phosphorylation in the frontal cortices, striata, and hippocampi. Representative Western blot images and densitometric measurements of HDAC2 abundance and fractional HDAC2 (Ser³⁹⁴) phosphorylation in frontal cortices, striata, and hippocampi. a HDAC2 abundance in frontal cortices (n_F1Veh = 14, n_F1NIC = 11, and n_F2NIC = 11). F1 NIC and F2 NIC mice have reduced frontal cortical HDAC2 content. b HDAC2 abundance in striata (n_F1Veh = 13, n_F1NIC = 12, and n_F2NIC = 12). Striatal HDAC2 content is unaltered in F1 NIC and F2 NIC mice. c HDAC2 abundance in hippocampi (n_F1Veh = 12, n_F1NIC = 13, and n_F2NIC = 13). F1 NIC and F2 NIC mice have reduced hippocampal HDAC2 content (d) Fractional HDAC2 (Ser³⁹⁴) phosphorylation in frontal cortices (n_F1Veh = 6, n_F1NIC = 5, and n_F2NIC = 5). F1 NIC and F2 NIC mice have increased frontal cortical fractional HDAC2 (Ser³⁹⁴) phosphorylation. e Fractional HDAC2 (Ser³⁹⁴) phosphorylation in striata (n_F1Veh = 5, n_F1NIC = 6, and n_F2NIC = 5). F1 NIC and F2 NIC mice have reduced striatal fractional HDAC2 (Ser³⁹⁴) phosphorylation. f Fractional HDAC2 (Ser³⁹⁴) phosphorylation in hippocampi (n_F1Veh = 6, n_F1NIC = 5, and n_F2NIC = 5). F1 NIC and F2 NIC mice have increased hippocampal fractional HDAC2 (Ser³⁹⁴) phosphorylation. FCX frontal cortices, STR striata, HIPP hippocampi, HDAC2 histone deacetylase 2, total total HDAC2, Phospho phospho-HDAC2 (Ser³⁹⁴), TBP TATA-binding protein. All data are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001