Table 3.
Multivariate Analyses of Prognostic Factors of tumor-related death among 568 patients using the ENETS, 8th AJCC, 7th AJCC and m7th AJCC staging systems including four tumor stages for pNECs
| Characteristic | ENETS | 8th AJCC | 7th AJCC | m7th AJCC | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | HR (95% CI) | P | ||
| Age, years | ||||||||
| < 60 | 1 | 1 | 1 | 1 | ||||
| ≥ 60 | 1.63 (1.33–2.00) | < 0.001 | 1.64 (1.34–2.01) | < 0.001 | 1.66 (1.35–2.03) | < 0.001 | 1.66 (1.35–2.03) | < 0.001 |
| Sex | ||||||||
| Female | 1 | 1 | 1 | 1 | ||||
| Male | 1.16 (0.95–1.41) | 0.15 | 1.16 (0.95–1.41) | 0.15 | 1.14 (0.94–1.40) | 0.18 | 1.14 (0.94–1.40) | 0.18 |
| Race | ||||||||
| Black | 1 | 1 | 1 | 1 | ||||
| White | 0.65 (0.48–0.88) | 0.01 | 0.66 (0.49–0.90) | 0.01 | 0.67 (0.50–0.91) | 0.01 | 0.67 (0.50–0.91) | 0.01 |
| Other | 0.65 (0.43–0.99) | 0.04 | 0.68 (0.45–1.04) | 0.07 | 0.68 (0.45–1.03) | 0.07 | 0.68 (0.45–1.03) | 0.07 |
| Location | ||||||||
| Body and tail | 1 | 1 | 1 | 1 | ||||
| Head | 1.63 (1.29–2.08) | < 0.001 | 1.61 (1.27–2.05) | < 0.001 | 1.60 (1.26–2.03) | < 0.001 | 1.60 (1.26–2.04) | < 0.001 |
| Others | 1.67 (1.29–2.15) | < 0.001 | 1.68 (1.30–2.17) | < 0.001 | 1.67 (1.21–2.15) | < 0.001 | 1.67 (1.29–2.16) | < 0.001 |
| Stage | ||||||||
| I | 1 | 1 | 1 | 1 | ||||
| II | 3.27 (0.77–14.02) | 0.11 | 0.74 (0.41–1.34) | 0.32 | 1.08 (0.60–1.94) | 0.80 | 1.23 (0.73–2.06) | 0.44 |
| III | 2.23 (0.54–9.18) | 0.27 | 1.81 (0.97–3.38) | 0.06 | 2.06 (0.94–4.52) | 0.07 | 2.20 (1.06–4.56) | 0.03 |
| IV | 9.59 (2.38–38.71) | 0.002 | 4.14 (2.52–6.79) | < 0.001 | 4.62 (2.73–7.83) | < 0.001 | 4.95 (3.20–7.65) | < 0.001 |
Abbreviations: AJCC American Joint Committee on Cancer; ENETS European Neuroendocrine Tumor Society; m7th AJCC modified 7th AJCC; pNECs poorly differentiated pancreatic neuroendocrine carcinomas; HR hazard ratio; CI confidence interval