Table 3.

Association between pesticide (ever/never use) and aggressive PCa for those pesticides first reported at follow-up (Phase 2 and Phase 3 questionnaires) in the Agricultural Health Study (AHS)

Common name	Follow-up questionnaire (Phase 2 and Phase 3)b N = 18,933
	Non-case	Aggressive PCa	HRa (95% CI)
Herbicide
Acetochlor
Never use	15,110	640	1
Ever use	3089	94	0.87 (0.70, 1.09)
Clethodim
Never use	17,526	717	1
Ever use	673	17	1.03 (0.64, 1.68)
Clopyralid
Never use	16,513	690	1
Ever use	1686	44	0.79 (0.58, 1.08)
Cloransulam-methyl
Never use	17,453	709	1
Ever use	746	25	1.13 (0.76, 1.69)
Dimethenamid
Never use	17,238	709	1
Ever use	961	25	0.82 (0.55, 1.23)
Fenoxaprop-p-ethyl
Never use	17,228	703	1
Ever use	971	31	1.00 (0.69, 1.44)
Flumetsulam
Never use	16,612	687	1
Ever use	1587	47	0.91 (0.67, 1.23)
Fomesafen
Never use	16,955	690	1
Ever use	1244	44	1.08 (0.80, 1.48)
Glufosinate-ammonium
Never use	16,538	692	1
Ever use	1661	42	0.81 (0.59, 1.11)
Isoxaflutole
Never use	17,172	703	1
Ever use	1027	31	1.03 (0.72, 1.49)
Maleic hydrazide
Never use	17,326	709	1
Ever use	873	25	0.91 (0.60, 1.38)
Mesotrione
Never use	16,312	692	1
Ever use	1887	42	0.80 (0.58, 1.10)
Nicosulfuron
Never use	15,931	674	1
Ever use	2268	60	0.78 (0.60, 1.03)
Picloram
Never use	15,848	652	1
Ever use	2351	82	0.97 (0.77, 1.23)
Rimsulfuron
Never use	16,728	694	1
Ever use	1471	40	0.83 (0.60, 1.15)
Triclopyr
Never use	16,788	699	1
Ever use	1411	35	0.68 (0.48, 0.95)
Insecticide
Cyfluthrin
Never use	16,399	691	1
Ever use	1800	43	0.81 (0.59, 1.10)
Lambda-cyhalothrin
Never use	17,257	712	1
Ever use	942	22	0.96 (0.63, 1.47)
Tebupirimfos
Never use	17,036	702	1
Ever use	1163	32	0.86 (0.60, 1.23)

^aUsing age as the time metric and adjusted for state, birth year, family history of PCa, race, and smoking status

^bNumbers may not add up to total, due to missing responses for pesticides