Table 2.

Corr and RMSE (kcal/mol) of ΔΔG estimation by different variants of MuPIPR using the SKP1400m dataset

N mut	All		1		2		≥3
MuPIPR variants	Corr	RMSE	Corr	RMSE	Corr	RMSE	Corr	RMSE
MuPIPR-static-noAux	0.773	1.832	0.741	1.783	0.794	2.032	0.744	2.001
MuPIPR-static	0.795	1.721	0.754	1.684	0.821	1.946	0.858	1.654
MuPIPR-CNN-noAux	0.819	1.596	0.779	1.559	0.829	1.728	0.797	1.773
MuPIPR-CNN	0.856	1.449	0.822	1.410	0.869	1.663	0.867	1.435
MuPIPR-noAux	0.853	1.462	0.829	1.406	0.848	1.751	0.860	1.473
MuPIPR	0.883	1.324	0.854	1.299	0.899	1.462	0.898	1.303