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. 2020 Mar 4;8(1):e001174. doi: 10.1136/bmjdrc-2020-001174

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Receiver operating characteristic curves of various non-invasive clinical scoring systems for the prediction of NASH among patients with NAFLD with persistent nALT: (A) using a cut-off of serum ALT levels <40 U/L for both sexes and (B) using a lower cut-off of serum ALT ≤35 U/L in men (n=48) and ≤23 U/L in women (n=16). The y-axis represents the sensitivity in ascending order. The x-axis represents the specificity in descending order. G-NASH is the model constructed by best-subset regression. Stepwise refers to the logistic regression model constructed by backward stepwise selection. ALT, alanine aminotransferase; AUROC, area under the receiver operating characteristic curve; CK18-M30, cytokeratin-18 M30 fragments; NAFLD, non-alcoholic fatty liver disease; nALT, normal ALT; NASH, non-alcoholic steatohepatitis.