. 2020 Mar 4;8(1):e001174. doi: 10.1136/bmjdrc-2020-001174

Table 3.

Performance of serum GP73 and CK18-M30 levels in diagnosing NASH in patients with persistent nALT

Tests results	Liver pathology results		Accuracy (%)	Se (%)	Sp (%)	PPV	NPV	P value*
Tests results	NASH	Non-NASH	Accuracy (%)	Se (%)	Sp (%)	PPV	NPV	P value*
GP73
Positive predictive	41	35	0.552	0.773	0.327	0.539	0.586	0.707
Negative predictive	12	17	0.552	0.773	0.327	0.539	0.586	0.707
CK18-M30
Positive predictive	5	1	0.516	0.100	0.978	0.821	0.516
Negative predictive	45	44

10 missing values in serum CK18-M30.

Diagnostic accuracy was calculated as the sum of true positive and true negative values divided by the total number of observations.

The cut-off value for normal serum ALT was <40 U/L for both sexes. Test results above the cut-off value (53 ng/mL for GP73 and 200 U/L for CK18-M30) were considered predictive of NASH.

*χ² test for comparing the diagnostic accuracy of serum GP73 and CK18-M30 levels.

ALT, alanine aminotransferase; CK18-M30, cytokeratin-18 M30 fragments; GP73, Golgi protein 73; nALT, normal ALT; NASH, non-alcoholic steatohepatitis; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity.