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. 2020 Feb 19;16:233–247. doi: 10.3762/bjoc.16.25

Table 2.

Chemical structures of title compound II, III and their biological activity against AtHPPD.

Inline graphic
II1–5, III1–6
compound R5 R AtHPPD inhibition
Ki (μM)
II1 2,3,5-trichloro-6-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i043.jpg 0.093 ± 0.007
II2 2,3,5-trichloro-6-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i044.jpg 0.097 ± 0.010
II3 2,3,5-trichloro-6-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i045.jpg 0.021 ± 0.004
II4 2,3,5-trichloro-6-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i046.jpg 0.023 ± 0.006
II5 2,3,5-trichloro-6-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i047.jpg 0.12 ± 0.003
III1 2-bromo-2-naphthyl graphic file with name Beilstein_J_Org_Chem-16-233-i048.jpg 2.50 ± 0.011
III2 2-bromo-2-naphthyl graphic file with name Beilstein_J_Org_Chem-16-233-i049.jpg 2.2 ± 0.090
III3 2-bromo-2-naphthyl graphic file with name Beilstein_J_Org_Chem-16-233-i050.jpg 2.2 ± 0.13
III4 2-bromo-2-naphthyl graphic file with name Beilstein_J_Org_Chem-16-233-i051.jpg 2.0 ± 0.012
III5 2-nitro-3-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i052.jpg 0.23 ± 0.011
III6 2-nitro-3-pyridyl graphic file with name Beilstein_J_Org_Chem-16-233-i053.jpg 0.21 ± 0.042
mesotrione 0.013 ± 0.001