A, Recorded position (left, red) and Aβ deposition in MEC (middle, WT; right, APP-KI). B, Theta-gamma cross-frequency coupling was diminished in the APP-KI mice as revealed by the vector length of theta-gamma phase-locking analysis (right). C, Gamma phase locking of layer II/III principal cells were impaired in the MEC of APP-KI mice, as revealed by the vector length of spike-gamma phase-locking analysis (right). Modified from Nakazono et al (2017).