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. 2020 Jan 28;15(8):1546–1553. doi: 10.4103/1673-5374.274341

Figure 6.

Figure 6

Differential scanning fluorimetry profile for the S. pilchardus chondroitin sulfate A extract.

(A) Thermal stability (first differential) profile of β-site amyloid precursor protein cleaving enzyme 1 (1 µg; black) and with 4 µg porcine mucosal heparin (green) or 4 µg S. pilchardus chondroitin sulfate A extract (blue), measured by differential scanning fluorimetry in 50 mM, pH 4.0, NaOAc buffer. ΔTm of β-site amyloid precursor protein cleaving enzyme 1 with 4 µg of porcine mucosal heparin (*** –10.5°C ± 0.5 SD, n = 3) or 4 µg S. pilchardus chondroitin sulfate A extract (** –5°C ± 1.3 SD, n = 3). (B) ΔTm of beta-site amyloid precursor protein cleaving enzyme 1 alone (black) or in the presence of increasing concentrations of porcine mucosal heparin or S. pilchardus chondroitin sulfate A extract.