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Cofilin activation in aged microglia leads to neuroinflammation.
In normal aging, the microglia morphology changed from ramified phenotype in resting state to dystrophic phenotype. We hypothesize that the morphological change due to an increase in the expression of active cofilin in aged microglia compared with young, resulting in activated other microglial cells, induce neuroinflammation, astrocyte activation and promote neuronal death.
