Fig. 7.

Number of self-administered “saline” doses as a function of cocaine dose that had previously maintained responding and HCRTr1 antagonist SB-334867 administration in 5 female rhesus monkeys. Responding was maintained under a Fixed interval 1 min; Fixed ratio 10 chain schedule [FI 1-min (FR10:S)] with a maximum of 15 drug infusions. Responding was tested under extinction (EXT) conditions when responding resulted in the presentation of the stimuli associated with cocaine but no drug was infused, then after a response-independent administration of a 0.3 mg/kg cocaine infusion prior to the session and after a response-independent administration of a 0.3 mg/kg cocaine infusion and 24 mg/kg SB-334867 administration (COC + SB) prior to the session: order of testing the latter 2 conditions was counterbalanced across monkeys.