Table 1.
Order of Testing Experimental Conditions.
| Hypocretin Manipulation | Cocaine Dose/Infusion | |
|---|---|---|
| Chain Schedule - [FI1’ (FR10:S)] | ||
| 1a) | HCRTr1 antagonist SB-334867 (24 mg/kg) | 0.05 mg/kg |
| 1b) | HCRTr1 antagonist SB-334867 (24 mg/kg) | 0.0125 mg/kg |
| 2) | d-Amphetamine (0.12, 0.25, 0.50 mg/kg) | 0.05 mg/kg |
| 3a) | Hypocretin-1 (0.072 mg/kg) | 0.025 mg/kg |
| 3b) | Hypocretin-1 (0.072 mg/kg) | 0.018 mg/kg |
| Cocaine-induced Reinstatement | ||
| 4a) | HCRTr1 antagonist SB-334867 (24 mg/kg) | 0.0125 mg/kg |
| 4b) | HCRTr1 antagonist SB-334867 (24 mg/kg) | 0.05 mg/kg |
| Cocaine vs. Candy Choice | ||
| 5) | Hypocretin-1 (0.072 mg/kg) | 0.0188 mg/kg |
| 6a) | HCRTr1 antagonist SB-334867 (8, 24 mg/kg) | 0.0188 mg/kg |
| 6a) | HCRTr1 antagonist SB-334867 (8, 24 mg/kg) | 0.025 mg/kg |
| Progressive Ratio Schedule | ||
| 7a) | HCRTr1 antagonist SB-334867 (4, 8, 24 mg/kg) | 0.05 mg/kg |
| 7b) | HCRTr1 antagonist SB-334867 (4, 8, 24 mg/kg) | 0.025 mg/kg |
| 8) | HCRTr1 antagonist RTIOX-276 (4, 8, 16 mg/kg) | 0.025 mg/kg |
HCRTr1 = hypocretin receptor-1.