Table 1.
Average values of ΔAERP, ΔQTc, and ΔHR from the start to the end of infusion of AP30663.
| AP30663 dose (mg/kg) |
ΔAERP | ΔHR | ΔQTc (ms) | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ms | p-value | % | p-value | bpm | p-value | % | p-value | |||
| 0 | 10 ± 3 | NA | 11 ± 3 | NA | −3 ± 4 | NA | −2 ± 3 | NA | −0.4 ± 1.7 | NA |
| 5 | 35 ± 6 | 0.047 | 33 ± 5 | 0.089 | −13 ± 3 | 0.300 | −8 ± 2 | 0.351 | 7.3 ± 1.7 | 0.277 |
| 10 | 43 ± 8 | 0.005 | 42 ± 9 | 0.008 | −23 ± 5 | 0.003 | −15 ± 3 | 0.006 | 3.5 ± 3.1 | 0.864 |
| 15 | 57 ± 8 | <0.001 | 50 ± 7 | <0.001 | −27 ± 5 | <0.001 | −19 ± 4 | <0.001 | 6.3 ± 3.4 | 0.418 |
| 20 | 65 ± 6 | <0.001 | 56 ± 5 | <0.001 | −22 ± 4 | 0.005 | −15 ± 3 | 0.006 | 7.9 ± 3.0 | 0.216 |
| 25 | 83 ± 7 | <0.001 | 71 ± 5 | <0.001 | −14 ± 5 | 0.187 | −11 ± 4 | 0.120 | 10.5 ± 3.8 | 0.055 |
Paired comparison of values after infusion of AP30663 to values after infusion of vehicle, n = 6. AERP, Atrial effective refractory period; QTc, Heart rate corrected QT interval, study specific formula; HR, Heart rate.