. 2019 Dec;16(12):1387–1394. doi: 10.2174/1570180815666181017131349

Table 1. Structures and rat activities for mGlu_2/4 PAM analogs 11.

Cpd	mGlu_2/4 EC₅₀ (μM)^a [% Glu Max ±SEM]	mGlu_2/4 pEC₅₀ (±SEM)
11a	5.2 [35±2]	5.28±0.03
11b	2.3 [24±1]	5.63±0.13
11c	0.76 [28±3]	6.12±0.23

^aThallium mobilization assays with rat mGlu_2/4-HEK293 cells performed in the presence of an EC₂₀ fixed concentration of glutamate; values represent means from three (n=3) independent experiments performed in triplicate.

Table 1. Structures and rat activities for mGlu2/4 PAM analogs 11.

Table 1. Structures and rat activities for mGlu_2/4 PAM analogs 11.