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. 2019 Dec;16(12):1387–1394. doi: 10.2174/1570180815666181017131349

Table 2. Structures and rat activities for mGlu2 PAM analogs 11.

graphic file with name LDDD-16-1387_t2-1.jpg
Cpd NR1R2 mGlu2
EC50 (μM)a
[% Glu Max ±SEM] 		mGlu2
pEC50
(±SEM)
11a graphic file with name LDDD-16-1387_t2-a.jpg 4.8
(73±30)		 5.32±0.02
11b graphic file with name LDDD-16-1387_t2-b.jpg 2.4
(53±6)		 5.62±0.11
11c graphic file with name LDDD-16-1387_t2-c.jpg 0.77
(57±6)		 6.11±0.08

aThallium mobilization assays with rat mGlu2-HEK293 cells performed in the presence of an EC20 fixed concentration of glutamate; values represent means from three (n=3) independent experiments performed in triplicate.