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. 2020 Mar 5;8:26. doi: 10.1186/s40478-020-00907-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Protein interaction networks highlight major role of astrocyte marker GFAP during aging. a Protein interaction network of proteins coded by genes down-regulated with age based on interactions from the BioGrid database. G-protein subunit alpha L (GNAL) is at the center of several clusters which are characterized by hub proteins BABAM1 (red), GNAS (yellow), TRIM25 (petrol), SPATA2 (green), APP (violet) and ELAVL1 (blue). b Protein interaction network of proteins coded by genes up-regulated with age based on interactions from the BioGrid database. The astrocyte marker-GFAP, has a central role and is directly connected to APP