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. 2020 Mar 6;27:40. doi: 10.1186/s12929-020-00635-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Inhibition of MALAT1 could protect astrocytes against the cell injury caused by ischemia- reperfusion. a. QPCR determining of the level of different LncRNAs under the OGD/RX conditions or Mock. b, c. The level of MALAT1 was determined by qPCR under different conditions. d. Transfected with the MALAT1 siRNA in OGD conditions decreased the LDH activity. e. Cell Calcein-AM/PI staining assay to determine cell viability. **P < 0.01,***P < 0.001 vs untreated; #P < 0.05,##P < 0.01,###P < 0.001 vs OGD/RX. f. QPCR examination of the interference efficiency of si-MALAT1. g. Flow cytometry analysis showing that compared with OGD/RX, the reduction of cell apoptosis following MALTA1 interference in OGD/RX conditions