Table 4.
Canonical pathways, diseases, and molecular and cellular functions significantly enriched in genes mapped to causal mQTLs.
| Top Canonical Pathways | p-value1 | Overlap2 |
|---|---|---|
| Amyloid processing | 6.79E-04 | 3.9% 2/51 |
| Palmitate biosynthesis | 1.52E-03 | 50.0% 1/2 |
| Fatty acid biosynthesis initiation II | 1.52E-03 | 50.0% 1/2 |
| Gas signaling | 2.94E-03 | 1.9% 2/107 |
| CDK5 signaling | 3.00E-03 | 1.9% 2/108 |
| Diseases and Disorders | p-value range 3 | #Molecules 4 |
| Neurological Disease | 4.90E-02–5.29E-04 | 5 |
| Organismal Injury and Abnormalities | 4.76E-02–5.29E-04 | 17 |
| Cancer | 4.69E-02–7.60E-04 | 17 |
| Cardiovascular Disease | 3.52E-02–7.60E-04 | 1 |
| Connective Tissue Disorders | 4.76E-02–7.60E-04 | 5 |
| Molecular and Cellular Functions | p-value range 3 | #Molecules 4 |
| Lipid Metabolism | 4.40E-02–3.16E-04 | 6 |
| Small Molecule Biochemistry | 4.40E-02–3.16E-04 | 7 |
| Nucleic Acid Metabolism | 1.21E-02–3.78E-04 | 5 |
| Cell Morphology | 4.76E-02–7.60E-04 | 5 |
| Cell-To-Cell Signaling and Interaction | 4.39E-02–7.60E-04 | 3 |
1The Fisher's exact test p-value indicating the significance of enrichment of the causal mQTL genes in the pathway.
2In a given pathway, the overlap is calculated as the number of causal mQTL genes enriched in the pathway divided by the total number of genes in that pathway.
3The Fisher's exact p-value indicating the range of enrichment in the subcategories of each disease/function.
4The number of genes that are associated with each disease/function.