Table 2.
Pharmacokinetic parameters of analytes after oral administration of paeonol to rats.
| Analytes | Dose (mg/kg) | V/F (L) | t 1/2 (h) | T max (h) | C max (μg/L) | AUC(0- t ) (μg/L*h) | AUC(0-∞) (μg/L*h) | MRT(0-t) (h) |
|---|---|---|---|---|---|---|---|---|
| paeonol | 12.5 | — | — | — | — | — | — | — |
| 25.0 | 31.69 ± 9.72 | 0.68 ± 0.22 | 0.18 ± 0.03 | 825.86 ± 150.06 | 539.78 ± 165.52 | 644.00 ± 174.00 | 0.55 ± 0.11 | |
| 50.0 | 21.84 ± 13.23 | 1.26 ± 1.13 | 0.19 ± 0.04 | 1588.71 ± 419.90 | 1332.76 ± 413.41 | 1654.22 ± 558.14 | 0.85 ± 0.38 | |
| M1 | 12.5 | 297.32 ± 156.06 | 3.33 ± 2.42 | 0.14 ± 0.10 | 154.33 ± 49.60 | 270.72 ± 144.15 | 325.04 ± 163.96 | 2.41 ± 1.67 |
| 25.0 | 285.93 ± 70.25 | 2.22 ± 0.66 | 0.12 ± 0.04 | 155.00 ± 93.85 | 201.63 ± 86.81 | 233.41 ± 84.44 | 1.80 ± 0.43 | |
| 50.0 | 43.11 ± 22.35 | 2.10 ± 0.97 | 0.24 ± 0.21 | 635.67 ± 223.35 | 1474.47 ± 523.82 | 1541.54 ± 519.67 | 2.49 ± 0.41 | |
| M2 | 12.5 | 9.92 ± 2.02 | 2.21 ± 0.27 | 0.22 ± 0.05 | 2830.00 ± 962.34 | 6271.13 ± 1770.92 | 6688.89 ± 2060.09 | 2.72 ± 0.49 |
| 25.0 | 9.19 ± 6.35 | 1.94 ± 1.25 | 0.20 ± 0.04 | 3155.71 ± 1004.07 | 5872.50 ± 1340.72 | 6277.51 ± 1976.69 | 3.19 ± 1.40 | |
| 50.0 | 4.39 ± 3.04 | 2.90 ± 2.40 | 0.50 ± 0.29 | 6844.29 ± 1630.09 | 18292.59 ± 5854.16 | 18568.62 ± 5870.21 | 2.60 ± 0.50 | |
| M3 | 12.5 | — | — | — | — | — | — | — |
| 25.0 | 23.78 ± 7.28 | 1.59 ± 0.90 | 0.56 ± 0.72 | 466.00 ± 213.53 | 1706.39 ± 477.94 | 1860.22 ± 573.75 | 6.51 ± 3.05 | |
| 50.0 | 7.92 ± 5.19 | 2.44 ± 1.24 | 0.79 ± 0.37 | 2497.83 ± 1142.88 | 9819.12 ± 3955.40 | 10003.57 ± 3981.12 | 3.80 ± 1.26 | |
| M4 | 12.5 | — | — | — | — | — | — | — |
| 25.0 | 108.64 ± 77.88 | 3.67 ± 1.84 | 5.50 ± 1.00 | 153.25 ± 62.65 | 1388.43 ± 499.10 | 1374.49 ± 486.22 | 8.28 ± 2.45 | |
| 50.0 | 59.52 ± 27.03 | 4.77 ± 2.10 | 4.06 ± 2.71 | 242.25 ± 86.70 | 1655.53 ± 811.52 | 2434.51 ± 613.28 | 5.94 ± 0.60 |
“—” means undetected.
(Mean ± SD, n=6).